“Cobra (Sildenafil): Shaping the Landscape of PDE5 Inhibition” refers to the drug sildenafil, which is also known by the brand name Viagra. Sildenafil is a PDE5 inhibitor, which means that it blocks the activity of an enzyme called phosphodiesterase type 5. PDE5 is responsible for breaking down cyclic guanosine monophosphate (cGMP), a molecule that plays a role in erectile function. By blocking the activity of PDE5, sildenafil helps to increase the levels of cGMP in the penis, which can lead to an erection.
Sildenafil was first approved by the FDA in 1998 for the treatment of erectile dysfunction. It has since become the most widely prescribed PDE5 inhibitor in the world. Sildenafil has also been shown to be effective for the treatment of pulmonary hypertension, a condition in which the blood pressure in the lungs is abnormally high.
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"Cobra (Sildenafil): Shaping the Landscape of PDE5 Inhibition" refers to the drug sildenafil, which is also known by the brand name Viagra. Sildenafil is a PDE5 inhibitor, which means that it blocks the activity of an enzyme called phosphodiesterase type 5. PDE5 is responsible for breaking down cyclic guanosine monophosphate (cGMP), a molecule that plays a role in erectile function. By blocking the activity of PDE5, sildenafil helps to increase the levels of cGMP in the penis, which can lead to an erection.
Sildenafil was first approved by the FDA in 1998 for the treatment of erectile dysfunction. It has since become the most widely prescribed PDE5 inhibitor in the world. Sildenafil has also been shown to be effective for the treatment of pulmonary hypertension, a condition in which the blood pressure in the lungs is abnormally high. - United States